Top 5 - best supplements with vitamin D3+K2
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Top 5 - 01/02/2026

Top 5 - best supplements with vitamin D3+K2

More and more people are turning to vitamin D3 supplements, especially during the fall and winter seasons, when the natural synthesis of this ingredient is greatly reduced. However, for long-term vitamin D supplementation, it is worthwhile to include vitamin K2, which, acting synergistically with vitamin D3, supports its properties and allows it to be used effectively especially in the context of maintaining bone health, cardiovascular health and calcium absorption. Taking vitamins D3 and K2 at the same time can bring tangible health benefits, provided the right preparation is selected. There are many supplements on the market containing these two valuable vitamins, but which product is worth reaching for? To make your choice easier, we have prepared a ranking of the 5 best supplements with vitamin D3+K2. Check our list and choose the most effective preparation.

Reviews and opinions of popular supplements with vitamin D3+K2

Benefits

  • Simple, natural composition.
  • High doses of vitamins D3 and K2.
  • With the addition of inulin.
  • It ensures bone and muscle health.
  • Strengthens immunity.
  • Supports calcium absorption.
  • Supports cardiovascular health.
  • Improves intestinal health.
  • Convenient and easy application.
  • Vegan formula.
  • Efficient packaging.
  • The price is commensurate with the quality.

Disadvantages

  • Available only in selected stores.

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Dietary supplement with vitamin D3+K2 from Nutridome brand in the form of vegan capsules provides comprehensive support for the immune, skeletal and cardiovascular systems. The product is characterized by a simple composition free of unnecessary substances, and the formula has been enriched with inulin (240 mg) - a natural prebiotic that supports intestinal microflora and strengthens the body's immunity. Regular use of the supplement supports bone and dental health, strengthens the muscular system and helps maintain normal blood calcium levels. The synergistic action of vitamins D3 and K2 ensures efficient utilization of calcium, preventing its accumulation in blood vessels. Nutridome supplement guarantees high bioavailability, and thanks to very good doses of vitamin D3 (4,000 IU) and K2 (200 μg) also effective action. The package of the product lasts for 60 days, the capsules are easy to take, and the price is adequate for the quality. Nutridome Vitamin D3+K2 is an excellent option for supporting bones, muscles and immunity throughout the year.

4.9
Effectiveness 5
Doses of vitamins D3 and K2 5
Ease of use 5
Price 4.6

Benefits

  • Simple composition.
  • Good doses of vitamins D and K.
  • Supports bone, tooth and muscle health.
  • Strengthens the body's immunity.
  • Supports the cardiovascular system.
  • Vegan formula.
  • Efficient packaging.

Disadvantages

  • Unpleasant to swallow uncoated tablets.
  • Limited availability.
  • Exorbitant price.

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The vegan dietary supplement from the German brand Gloryfeel is characterized by its simple composition, effective action and adequate doses of vitamins. The product contains 2000 IU (50 µg) of vitamin D3 and 200 µg of vitamin K2 in the form of MK-7 (menaquinone-7), the best-absorbed form, in a daily serving. The use of the supplement primarily ensures the health of bones, teeth and muscles. In addition, it strengthens the body's immunity and supports cardiovascular health by preventing calcium deposition in blood vessels. The package of the supplement is very efficient and lasts for as much as 100 days of use. The only drawbacks of Gloryfeel are the uncoated tablets and the somewhat exorbitant price.

4.38
Effectiveness 4.8
Doses of vitamins D3 and K2 4.8
Ease of use 3.9
Price 4

Benefits

  • A good dose of vitamin D3.
  • Supports the health of the skeletal, muscular and cardiovascular systems.
  • Strengthens the body's immunity.
  • Suitable for vegans and vegetarians.
  • Efficient packaging.
  • Affordable price.

Disadvantages

  • There could be more vitamin K.
  • Caloric maltodextrin in the formulation.
  • Unpleasant smell of capsules.

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The supplement from the well-known brand Swanson is an effective and comprehensive way to support the health of the musculoskeletal system. Each vegetable capsule contains 2000 IU (50 µg) of vitamin D3 in the form of cholecalciferol from seaweed, and 75 µg of vitamin K2 in the form of menaquinone-7 extracted from fermented soybeans (natto). Regular use of the capsules supports the health of bones, teeth, joints and muscles. In addition, it strengthens immunity and supports cardiovascular health. The recommended daily serving is only 1 capsule, which benefits the performance of the package. Another advantage of the supplement is its affordable price.

4.3
Effectiveness 4.6
Doses of vitamins D3 and K2 3.9
Ease of use 4.2
Price 4.5

Benefits

  • Supports bone and dental health.
  • Strengthens immunity.
  • Ensures proper calcium levels.
  • Supports cardiovascular health.
  • Efficient packaging.
  • Favorable price.

Disadvantages

  • In the composition of thickeners and anti-caking agents.
  • Small doses of vitamins D and K.
  • Large capsules.
  • Impeded application.

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The dietary supplement from the American brand Now Foods is another vegan formulation in our list. The formula contains a combination of vitamin D3 (1000 IU/per serving) and vitamin K2 (45 µg/per serving). Unfortunately, these are not the best doses of these valuable vitamins, especially for adults during the fall and winter, when the need for D3 increases. Nevertheless, regular use of the supplement is intended to support bone and dental health, strengthen immunity, ensure proper calcium levels in the body, and support the proper functioning of the cardiovascular system. A package of the Now Foods supplement is efficient and lasts for 120 days of use, and the price of the capsules is favorable.

4.1
Effectiveness 4.5
Doses of vitamins D3 and K2 3.6
Ease of use 3.7
Price 4.6

Benefits

  • With a complex of ingredients to support the skeletal system.
  • It improves the condition of teeth and bones.
  • Supports the maintenance of normal connective tissues.
  • It supports the cardiovascular system.
  • Strengthens immunity.
  • Dark glass jar.

Disadvantages

  • Small doses of vitamins D and K.
  • Low content of zinc and calcium.
  • 3 tablets of daily intake.
  • High price inadequate for performance.

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Solgar's dietary supplement in the form of vegan tablets is a combination of vitamin D3, K2, magnesium, zinc and boron for the best possible support of bone health. A daily serving of as many as 3 tablets places only 750 IU (18.75 μg) of vitamin D3 and 48.75 μg of vitamin K2. Also, the doses of zinc and calcium do not cover the daily recommended intake. Use of the supplement is intended to improve bone, muscle and dental health, strengthen immunity, support the cardiovascular system and maintain normal connective tissues. A package of the supplement lasts for 40 days, which makes its price really very high. An advantage of the Solgar supplement is the dark glass packaging, which protects the contents from harmful light.

3.85
Effectiveness 4.3
Doses of vitamins D3 and K2 3.5
Ease of use 4
Price 3.6

Vitamin D3+K2 supplements - synergistic action for bone health 

Supplements containing a combination of vitamins D3 and K2 are increasingly popular, especially in the context of preventing osteoporosis and supporting bone health. Their synergistic effect is that vitamin D3 increases the absorption of calcium from the gastrointestinal tract, while vitamin K2 is responsible for its proper utilization, as it activates proteins that transport calcium to the bones and teeth, while preventing its accumulation in the arteries. Thanks to this combination, calcium not only goes where it is needed, but also does not endanger the cardiovascular system. Regular use of vitamin D3+K2 supplements maintains strong bones, reduces the risk of fractures and supports the body's overall calcium-phosphate balance. It is an extremely effective way that works comprehensively and multilevelly - supporting both the structure of the skeleton and the health of the entire body. 

How to choose the best vitamin D3+K2 supplement?

In creating our ranking of the best supplements with vitamin D3+K2, we took into account the following criteria:  

What doses of vitamins D and K does the supplement contain?

Is it effective in improving bone health?

Is the composition of the supplement simple? 

Are there any unnecessary substances in it that may be harmful to health?

Is there oil in the composition of the supplement? 

Is the supplement easy to use? 

Does it cause no adverse reactions? 

Is the packaging efficient? 

Is the price of the supplement commensurate with the quality and effectiveness? 

What are the appropriate daily doses of vitamins D and K? 

Doses of vitamin D are most often given in IU (International Unit), the international unit used to indicate the amount of biologically active substances, such as vitamins or hormones. In the case of vitamin D, the IU indicates its biological activity, not its weight. For example: 

IU makes it easier to compare dosages of preparations, regardless of the chemical form of vitamin D.

Vitamin D dosage for different age groups

Preferably, before starting supplementation, consult a doctor and take a blood test to determine the need for vitamin D3. Its daily dosage depends on time spent in the sun, complexion, age, health and body weight.  

Dosage of vitamin K

For vitamin K, dosages are not strictly defined and vary from country to country. According to the European Food Safety Authority, the appropriate intake of vitamin K is 1 μg/kg body weight for adults, children and pregnant women. Doses of vitamin K for children are assumed to be about 10-60 µg/day, and for adults about 90-120 µg/day.

What is vitamin D3? 

Vitamin D3 (cholecalciferol) is one of the two main forms of vitamin D - along with vitamin D2 (ergocalciferol). Vitamin D3 is naturally synthesized in our skin when exposed to UVB radiation. It is also found in some animal products, such as fatty fish, egg yolks and liver. However, it is virtually impossible to make up for deficiencies of this vitamin with diet alone, and therefore it should be supplemented especially during the fall and winter. 

The main effects of vitamin D3 are: 

What is vitamin K2? 

Vitamin K2 (menaquinone) is a fat-soluble vitamin, one of the two main forms of vitamin K - along with vitamin K1 (phylloquinone). Vitamin K2 is mainly found in animal products and fermented foods. It is also produced in small amounts by intestinal bacteria. Vitamin K2 plays a key role in processes related to blood clotting, bone health and the cardiovascular system.  

Main actions of vitamin K2 include: 

Vitamin D3+K2 - action 

Vitamin D3 and K2 are often supplemented together because their actions in the body are closely related and complementary. Vitamin D3 is responsible for increasing the absorption of calcium from the gastrointestinal tract into the blood. However, increasing calcium levels alone may not be enough for bone health, because instead of going to the bones, it can be deposited in soft tissues like blood vessels. And that's when vitamin K2 comes to the rescue. Vitamin K2 activates two important proteins: osteocalcin and MGP (Matrix Gla Protein). The former directs calcium to the bones and teeth, promoting their mineralization and strengthening their structure. The second prevents calcium deposition in the arteries, which could lead to atherosclerosis or other cardiovascular diseases. In short, vitamin D3 provides calcium, and vitamin K2 helps to utilize it properly. This is why these two vitamins are often found together in supplements, and it is recommended to take them at the same time, especially for long-term supplementation with higher doses of vitamin D3. 

What is the best vitamin D3+K2 supplement? 

The best vitamin D3+K2 supplement should contain natural vitamin D3 (cholecalciferol) and vitamin K2 in the MK-7 form, as this is the most stable and best absorbed form of K2. The supplement should have a simple formulation and contain oil, as both vitamins are fat-soluble and the presence of oil significantly increases their absorption. In addition, the formula should be convenient to use, efficient and inexpensive. 

How to use vitamin D3+K2 supplements?

Vitamin D3+K2 supplements are best taken once a day, with a meal containing fat, as both vitamins are fat-soluble and are then best absorbed. Dosage should be adjusted according to individual needs, age, weight, season and blood vitamin D levels. For example, in the fall and winter, doses of 2000-4000 IU of vitamin D3 per day, combined with about 75-100 µg of vitamin K2, are often recommended. For those taking anticoagulants or having chronic diseases, supplementation should be consulted with a doctor. 

What are the benefits of vitamin D3+K2 supplements?

The most important benefits of taking vitamin D3+K2 supplements include: